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Researchers believe this reduction may partly contribute to slower healing, collagen loss, inflammation, tissue degeneration, and visible signs of aging

In this regard, synthetic biomaterials such as poly-(lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) hydrogels have been employed to improve tissue integration and reduce immune responses

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While high-dose B12 is generally safe, its still important to use supplements thoughtfully and pay attention to any unusual symptoms